Cytochrome P450 1A2

BE0002433ProteinHumansCYP1A2

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). It is acted on by 434 drugs in DrugBank.

Gene name
CYP1A2
UniProtKB entry
P05177Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
516 residues · 58,407 Da
Also known as
1.14.14.1 · Cholesterol 25-hydroxylase · CYPIA2 · Cytochrome P(3)450 · Cytochrome P450 4

Resolves to

Protein
UniProtP05177UniProt nameCP1A2_HUMAN
Gene
HGNCHGNC:2596NCBI Gene1544GeneCardsCYP1A2
Pharmacology
IUPHAR/GtoPdb1319KEGGhsa:1544
Structure
PDB2HI4
Drugs

What you can answer from here — as of September 07, 2019

434DrugsApproved to experimental, with action, bond type and pharmacological action
Sign in
5Clinical trialsTrials of drugs acting on it, by phase and status
Sign in
252Metabolic reactionsDrug transformations it catalyses, substrate to product
Sign in
15GO termsFunction, process and component, as structured annotations
Sign in
1Pfam domainDomain architecture mapped to Pfam families and clans
Sign in
1,107+ReferencesStructured and connected to the statements they support
Sign in

Which approved drugs act on Cytochrome P450 1A2, how selective are they, and which programs against it are still in active trials?

Answer this in Biopharma OSSign in to your account

Create a free account or log in to explore the full data card.

Create Account
Log InPaid Account Log In