Reaction: Colchicine to 1 product

Reaction
Colchicine
DB01394
    Colchiceine
    DB15534
    Reaction type
    demethylation
    Direction
    Major circulating metabolite?
    No
    Spontaneous?
    No
    Activity
    unknown
    References
    1. Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ: Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation. Biochem Pharmacol. 1997 Jan 10;53(1):111-6. doi: 10.1016/s0006-2952(96)00693-4. [Article]
    2. FDA Approved Drug Products: Colcrys (colchicine) tablets for oral use (May 2020) [Link]
    Comments
    Not Available
    Enzymes
    Not Available