Reaction: Isavuconazonium to 2 products

Reaction
Isavuconazonium
DB06636
BAL8728
DBMET03758
Isavuconazole
DB11633
Reaction type
hydrolysis
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Townsend R, Kato K, Hale C, Kowalski D, Lademacher C, Yamazaki T, Akhtar S, Desai A: Two Phase 1, Open-Label, Mass Balance Studies to Determine the Pharmacokinetics of (14) C-Labeled Isavuconazonium Sulfate in Healthy Male Volunteers. Clin Pharmacol Drug Dev. 2018 Feb;7(2):207-216. doi: 10.1002/cpdd.376. Epub 2017 Jul 27. [Article]
  2. FDA Approved Drug Products: CRESEMBA® (isavuconazonium sulfate) capsules/injection, for oral/intravenous use [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
CholinesteraseNot AvailableNot Availableimplied