Cholinesterase

BE0002180ProteinHumansBCHE

Esterase with broad substrate specificity. It is acted on by 119 drugs in DrugBank.

Gene name
BCHE
UniProtKB entry
P06276Swiss-Prot
Cellular location
Secreted
Residues / weight
602 residues · 68,418 Da
Also known as
3.1.1.8 · Acylcholine acylhydrolase · Butyrylcholine esterase · CHE1 · Choline esterase II

Resolves to

Protein
UniProtP06276UniProt nameCHLE_HUMAN
Gene
HGNCHGNC:983NCBI Gene590GenBank1311630GeneCardsBCHE
Pharmacology
IUPHAR/GtoPdb2471KEGGhsa:590
Structure
PDB1P0IPDB1P0MPDB1P0P
Drugs

What you can answer from here — as of September 07, 2019

119DrugsApproved to experimental, with action, bond type and pharmacological action
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12Clinical trialsTrials of drugs acting on it, by phase and status
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14Metabolic reactionsDrug transformations it catalyses, substrate to product
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7GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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312+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cholinesterase, how selective are they, and which programs against it are still in active trials?

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