Azelastine hydrochlorideProduct ingredient for Azelastine

Name
Azelastine hydrochloride
Drug Entry
Azelastine

Azelastine, a phthalazine derivative, is an antihistamine available as an intranasal spray for the treatment of allergic and vasomotor rhinitis and as an ophthalmic solution for the treatment of allergic conjunctivitis.10,11 It is a racemic mixture, though there is no noted difference in pharmacologic activity between enantiomers, and was first granted FDA approval in 1996.10,11 Azelastine is also available in combination with fluticasone propionate as a nasal spray marketed under the trade name Dymista™, which is indicated for the symptomatic treatment of seasonal allergic rhinitis in patients 6 years of age and older.13

Accession Number
DBSALT000013
Structure
Synonyms
Azelastine HCl
UNII
0L591QR10I
CAS Number
79307-93-0
Weight
Average: 418.359
Monoisotopic: 417.137467851
Chemical Formula
C22H25Cl2N3O
InChI Key
YEJAJYAHJQIWNU-UHFFFAOYSA-N
InChI
InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
IUPAC Name
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one hydrochloride
SMILES
Cl.CN1CCCC(CC1)N1N=C(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2C1=O
PubChem Compound
54360
ChemSpider
49103
ChEBI
2951
ChEMBL
CHEMBL1200809
Wikipedia
Azelastine
Predicted Properties
PropertyValueSource
Water Solubility0.0092 mg/mLALOGPS
logP3.81ALOGPS
logP4.04Chemaxon
logS-4.6ALOGPS
pKa (Strongest Basic)8.88Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area35.91 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity110.52 m3·mol-1Chemaxon
Polarizability42.04 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon