Cysteamine hydrochlorideProduct ingredient for Cysteamine

Name
Cysteamine hydrochloride
Drug Entry
Cysteamine

Cystinosis is a rare disease caused by mutations in the CTNS gene that encodes for cystinosin, a protein responsible for transporting cystine out of the cell lysosome. A defect in cystinosin function is followed by cystine accumulation throughout the body, especially the eyes and kidneys.2

Several preparations of cysteamine exist for the treatment of cystinosis manifestations, some in capsule form, and others in ophthalmic solution form.10,12 In particular, cystine deposits on the eye can cause significant discomfort throughout the day and require frequent treatment with eye drops, typically every waking hour.11

On August 25th 2020, the first ophthalmic solution for cystinosis requiring only 4 daily treatments was granted FDA approval.10 Cysteamine eye drops are a practical and effective option for those affected by ocular cystinosis. Marketed by Recordati Rare Diseases Inc., CYSTADROPS® reduce the burden of multiple frequent medications normally administered to those with cystinosis.9

Accession Number
DBSALT000033
Structure
Thumb
Synonyms
2-aminoethanethiol hydrochloride / Cysteamine HCl / Cysteamine hydrochloride / Cysteaminhydrochlorid / Cysteaminium chloride / Mercamine hydrochloride / Mercaptamine HCl / Mercaptamine hydrochloride / Mercaptoethylamine hydrochloride
External IDs
CI-9148
UNII
IF1B771SVB
CAS Number
156-57-0
Weight
Average: 113.61
Monoisotopic: 113.006597658
Chemical Formula
C2H8ClNS
InChI Key
OGMADIBCHLQMIP-UHFFFAOYSA-N
InChI
InChI=1S/C2H7NS.ClH/c3-1-2-4;/h4H,1-3H2;1H
IUPAC Name
2-aminoethane-1-thiol hydrochloride
SMILES
Cl.NCCS
PubChem Compound
9082
ChemSpider
8729
ChEBI
805121
ChEMBL
CHEMBL1256137
Wikipedia
Cysteamine
Predicted Properties
PropertyValueSource
Water Solubility23.5 mg/mLALOGPS
logP0.01ALOGPS
logP-0.42ChemAxon
logS-0.52ALOGPS
pKa (Strongest Acidic)9.42ChemAxon
pKa (Strongest Basic)10.4ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area26.02 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity22.39 m3·mol-1ChemAxon
Polarizability8.65 Å3ChemAxon
Number of Rings0ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon