Fluvastatin sodiumProduct ingredient for Fluvastatin
- Name
- Fluvastatin sodium
- Drug Entry
- Fluvastatin
Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Fluvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. It is also the first entirely synthetic HMG-CoA reductase inhibitor and is structurally distinct from the fungal derivatives of this therapeutic class. Fluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin.
- Accession Number
- DBSALT000088
- Structure
- Synonyms
- Not Available
- External IDs
- XU 62-320 / XU-62-320
- UNII
- PYF7O1FV7F
- CAS Number
- 93957-55-2
- Weight
- Average: 433.455
Monoisotopic: 433.16653073 - Chemical Formula
- C24H25FNNaO4
- InChI Key
- ZGGHKIMDNBDHJB-CALJPSDSSA-M
- InChI
- InChI=1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;
- IUPAC Name
- sodium (6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
- SMILES
- [Na+].CC(C)N1C(\C=C\C(O)CC(O)CC([O-])=O)=C(C2=CC=CC=C12)C1=CC=C(F)C=C1
- External Links
- PubChem Compound
- 24906289
- ChemSpider
- 8086370
- BindingDB
- 200236
- ChEBI
- 77602
- ChEMBL
- CHEMBL2218894
- Wikipedia
- Fluvastatin
- Predicted Properties
Property Value Source Water Solubility 0.0039 mg/mL ALOGPS logP 4.17 ALOGPS logP 3.83 Chemaxon logS -5 ALOGPS pKa (Strongest Acidic) 4.54 Chemaxon pKa (Strongest Basic) -2.8 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 85.52 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 125.69 m3·mol-1 Chemaxon Polarizability 43.19 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon