Losartan potassiumProduct ingredient for Losartan
- Name
- Losartan potassium
- Drug Entry
- Losartan
Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension.3 Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough.3 When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide.3 Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide.3,4 Patients taking losartan should have their renal function and potassium levels monitored.3 Losartan was granted FDA approval on 14 April 1995.3
- Accession Number
- DBSALT000112
- Structure
- Synonyms
- Not Available
- UNII
- 3ST302B24A
- CAS Number
- 124750-99-8
- Weight
- Average: 461.001
Monoisotopic: 460.118068924 - Chemical Formula
- C22H22ClKN6O
- InChI Key
- OXCMYAYHXIHQOA-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
- IUPAC Name
- potassium 5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}-[1,1'-biphenyl]-2-yl)-1,2,3,4-tetrazol-2-uide
- SMILES
- [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NN=[N-]=N1
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.0216 mg/mL ALOGPS logP 5.37 ALOGPS logP 4.48 Chemaxon logS -4.3 ALOGPS pKa (Strongest Acidic) 14.22 Chemaxon pKa (Strongest Basic) 3.89 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 75.13 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 122.85 m3·mol-1 Chemaxon Polarizability 44.5 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon