Losartan potassiumProduct ingredient for Losartan

Name
Losartan potassium
Drug Entry
Losartan

Losartan is an angiotensin II receptor blocker (ARB) used to treat hypertension.3 Angiotensin-converting enzyme (ACE) inhibitors are used for a similar indication but are associated with a cough.3 When patients with ACE inhibitor associated coughs are switched to ARBs like losartan, they have an incidence of cough similar to placebo or hydrochlorothiazide.3 Losartan is available as losartan potassium oral tablets as well as a combination tablet of losartan potassium and hydrochlorothiazide.3,4 Patients taking losartan should have their renal function and potassium levels monitored.3 Losartan was granted FDA approval on 14 April 1995.3

Accession Number
DBSALT000112
Structure
Synonyms
Not Available
UNII
3ST302B24A
CAS Number
124750-99-8
Weight
Average: 461.001
Monoisotopic: 460.118068924
Chemical Formula
C22H22ClKN6O
InChI Key
OXCMYAYHXIHQOA-UHFFFAOYSA-N
InChI
InChI=1S/C22H22ClN6O.K/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22;/h4-7,9-12,30H,2-3,8,13-14H2,1H3;/q-1;+1
IUPAC Name
potassium 5-(4'-{[2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl}-[1,1'-biphenyl]-2-yl)-1,2,3,4-tetrazol-2-uide
SMILES
[K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NN=[N-]=N1
PubChem Compound
11476710
ChemSpider
54768
ChEBI
209797
ChEMBL
CHEMBL995
Wikipedia
Losartan
Predicted Properties
PropertyValueSource
Water Solubility0.0216 mg/mLALOGPS
logP5.37ALOGPS
logP4.48Chemaxon
logS-4.3ALOGPS
pKa (Strongest Acidic)14.22Chemaxon
pKa (Strongest Basic)3.89Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area75.13 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity122.85 m3·mol-1Chemaxon
Polarizability44.5 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon