Naphazoline hydrochlorideProduct ingredient for Naphazoline

Name
Naphazoline hydrochloride
Drug Entry
Naphazoline

Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles6,7. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations6,7.

Naphazoline was first developed in 1942 as a nasal formulation for congestion4.

Accession Number
DBSALT000127
Structure
Thumb
Synonyms
Naphazoline HCl
UNII
MZ1131787D
CAS Number
550-99-2
Weight
Average: 246.735
Monoisotopic: 246.092376197
Chemical Formula
C14H15ClN2
InChI Key
DJDFFEBSKJCGHC-UHFFFAOYSA-N
InChI
InChI=1S/C14H14N2.ClH/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;/h1-7H,8-10H2,(H,15,16);1H
IUPAC Name
2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole hydrochloride
SMILES
Cl.C(C1=NCCN1)C1=CC=CC2=CC=CC=C12
KEGG Compound
C07898
PubChem Compound
11079
ChemSpider
10608
ChEBI
7470
ChEMBL
CHEMBL1706
Wikipedia
Naphazoline
Predicted Properties
PropertyValueSource
Water Solubility0.0381 mg/mLALOGPS
logP3.44ALOGPS
logP2.19ChemAxon
logS-3.7ALOGPS
pKa (Strongest Basic)10.19ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area24.39 Å2ChemAxon
Rotatable Bond Count2ChemAxon
Refractivity65.52 m3·mol-1ChemAxon
Polarizability23.78 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon