Amiloride hydrochloride dihydrateProduct ingredient for Amiloride
- Name
- Amiloride hydrochloride dihydrate
- Drug Entry
- Amiloride
A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)
- Accession Number
- DBSALT000270
- Structure
- Synonyms
- Amiloride hydrochloride dehydrate
- UNII
- FZJ37245UC
- CAS Number
- 17440-83-4
- Weight
- Average: 302.119
Monoisotopic: 301.045692731 - Chemical Formula
- C6H13Cl2N7O3
- InChI Key
- LTKVFMLMEYCWMK-UHFFFAOYSA-N
- InChI
- InChI=1S/C6H8ClN7O.ClH.2H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;;/h(H4,8,9,13)(H4,10,11,14,15);1H;2*1H2
- IUPAC Name
- 3,5-diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide dihydrate hydrochloride
- SMILES
- O.O.Cl.NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N
- External Links
- KEGG Drug
- D00649
- PubChem Compound
- 68540
- ChemSpider
- 61814
- ChEBI
- 2640
- ChEMBL
- CHEMBL1398126
- Predicted Properties
Property Value Source Water Solubility 0.616 mg/mL ALOGPS logP -0.48 ALOGPS logP -0.5 Chemaxon logS -2.6 ALOGPS pKa (Strongest Acidic) 11.43 Chemaxon pKa (Strongest Basic) 7.35 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 156.79 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 67.18 m3·mol-1 Chemaxon Polarizability 20.01 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon