Allopurinol sodiumProduct ingredient for Allopurinol
- Name
- Allopurinol sodium
- Drug Entry
- Allopurinol
Gout is a disease that occurs by the deposition of monosodium urate crystals (MSU) in body tissues, especially around joints 7. This disease has been well-documented in historical medical records and appears in the biographies of several prominent, historically recognized individuals 7.
Allopurinol is a xanthine oxidase enzyme inhibitor that is considered to be one of the most effective drugs used to decrease urate levels and is frequently used in the treatment of chronic gout 6. It was initially approved by the FDA in 1966 12 and is now formulated by several manufacturers 13.
- Accession Number
- DBSALT000350
- Structure
Structure for Allopurinol sodium (DBSALT000350)
- Synonyms
- Sodium allopurinol
- UNII
- 428673RC2Z
- CAS Number
- 17795-21-0
- Weight
- Average: 158.0933
Monoisotopic: 158.020455413 - Chemical Formula
- C5H3N4NaO
- InChI Key
- PTJRZVJXXNYNLN-UHFFFAOYSA-M
- InChI
- InChI=1S/C5H4N4O.Na/c10-5-3-1-8-9-4(3)6-2-7-5;/h1-2H,(H2,6,7,8,9,10);/q;+1/p-1
- IUPAC Name
- sodium 1H-pyrazolo[3,4-d]pyrimidin-4-olate
- SMILES
- [Na+].[O-]C1=NC=NC2=C1C=NN2
- External Links
- PubChem Compound
- 23662349
- ChemSpider
- 26766
- ChEBI
- 774428
- ChEMBL
- CHEMBL1200477
- Wikipedia
- Allopurinol
- Predicted Properties
Property Value Source Water Solubility 34.6 mg/mL ALOGPS logP -0.1 ALOGPS logP 0.031 Chemaxon logS -0.66 ALOGPS pKa (Strongest Acidic) 8.47 Chemaxon pKa (Strongest Basic) 1.25 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 77.52 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 45.53 m3·mol-1 Chemaxon Polarizability 11.31 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon