Ranitidine hydrochlorideProduct ingredient for Ranitidine

Name
Ranitidine hydrochloride
Drug Entry
Ranitidine

Ranitidine is a commonly used drug, classified as a histamine H2-receptor antagonist, and belongs to the same drug class as cimetidine and famotidine. This drug helps to prevent and treat gastric-acid associated conditions, including ulcers, because of its ability to decrease gastric acid secretion.2,11 Ranitidine is often referred to as Zantac, and is available in various forms, including tablet, injection, and effervescent tablet preparations.11,14

The prevalence of GERD is thought to be 10-20% in western countries.4 Ranitidine has proven to be an effective treatment for relieving uncomfortable symptoms of gastric acid associated conditions and is therefore widely used in GERD and other gastric-acid related conditions.5,11

Accession Number
DBSALT000487
Structure
Thumb
Synonyms
Ranitidine HCl
External IDs
AH 19065 / AH-19065
UNII
BK76465IHM
CAS Number
66357-59-3
Weight
Average: 350.86
Monoisotopic: 350.1179395
Chemical Formula
C13H23ClN4O3S
InChI Key
GGWBHVILAJZWKJ-UHFFFAOYSA-N
InChI
InChI=1S/C13H22N4O3S.ClH/c1-14-13(9-17(18)19)15-6-7-21-10-12-5-4-11(20-12)8-16(2)3;/h4-5,9,14-15H,6-8,10H2,1-3H3;1H
IUPAC Name
[1-({2-[({5-[(dimethylamino)methyl]furan-2-yl}methyl)sulfanyl]ethyl}amino)-2-nitroethenyl](methyl)amine hydrochloride
SMILES
Cl.CNC(NCCSCC1=CC=C(CN(C)C)O1)=C[N+]([O-])=O
PubChem Compound
3033332
ChemSpider
43590
ChEBI
8777
ChEMBL
CHEMBL2110372
Wikipedia
Ranitidine
Predicted Properties
PropertyValueSource
Water Solubility0.0795 mg/mLALOGPS
logP0.79ALOGPS
logP0.99ChemAxon
logS-3.6ALOGPS
pKa (Strongest Basic)7.8ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area83.58 Å2ChemAxon
Rotatable Bond Count10ChemAxon
Refractivity94.15 m3·mol-1ChemAxon
Polarizability33.78 Å3ChemAxon
Number of Rings1ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon