Cimetidine is a histamine H2 receptor antagonist used to manage GERD, peptic ulcer disease, and indigestion. A histamine congener, it competitively inhibits histamine binding to histamine H2 receptors.
- Mechanism
- Curator reviewed
Cimetidine binds to an H2-receptor located on the basolateral membrane of the gastric parietal cell, blocking histamine effects. This competitive inhibition results in reduced gastric acid secretion and a reduction in gastric volume and acidity.
- Primary indication
- Cimetidine is indicated to reduce gastric acid secretion and to treat the following disease states: duodenal ulcers, non-malignant gastric ulcers, gastroesophageal reflux disease, and pathological hypersecretion associated with Zollinger-Ellison Syndrome, systemic mastocytosis, and multiple endocrine...Curator reviewed · 16 structured indications
- Formula / weight
- C10H16N6S · 252.339 g/mol (avg)
- First approval
- Canada, 1996 · United States, 1994
- Code names
- NSC-335308 · SKF-92334
- Brand names
Resolves to
Clinical / RWD
Structure
InChIKey
AQIXAKUUQRKLND-UHFFFAOYSA-NSMILESCN\C(NCCSCC1=C(C)NC=N1)=N\C#NTargets
What you can answer from here — as of September 21, 2026
2Protein targetsEach mapped to UniProt, with action and pharmacological actionListed above
14TransportersSubstrate / inhibitor direction, not just membershipListed above
Which drugs share a target with Cimetidine, and which of those have an active Phase 3 trial?
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