Ambroxol hydrochlorideProduct ingredient for Ambroxol
- Name
- Ambroxol hydrochloride
- Drug Entry
- Ambroxol
Ambroxol is a secretolytic agent used in the treatment of respiratory diseases associated with viscid or excessive mucus. It is the active ingredient of Mucosolvan, Lasolvan or Mucoangin. The substance is a mucoactive drug with several properties including secretolytic and secretomotoric actions that restore the physiological clearance mechanisms of the respiratory tract which play an important role in the body’s natural defence mechanisms. It stimulates synthesis and release of surfactant by type II pneumocytes. Surfactants acts as an anti-glue factor by reducing the adhesion of mucus to the bronchial wall, in improving its transport and in providing protection against infection and irritating agents.
- Accession Number
- DBSALT000563
- Structure
Structure for Ambroxol hydrochloride (DBSALT000563)
- Synonyms
- Ambroxol HCl
- UNII
- CC995ZMV90
- CAS Number
- 23828-92-4
- Weight
- Average: 414.57
Monoisotopic: 411.955267 - Chemical Formula
- C13H19Br2ClN2O
- InChI Key
- QNVKOSLOVOTXKF-PFWPSKEQSA-N
- InChI
- InChI=1S/C13H18Br2N2O.ClH/c14-9-5-8(13(16)12(15)6-9)7-17-10-1-3-11(18)4-2-10;/h5-6,10-11,17-18H,1-4,7,16H2;1H/t10-,11-;
- IUPAC Name
- (1r,4r)-4-{[(2-amino-3,5-dibromophenyl)methyl]amino}cyclohexan-1-ol hydrochloride
- SMILES
- Cl.NC1=C(Br)C=C(Br)C=C1CN[C@H]1CC[C@H](O)CC1
- External Links
- KEGG Drug
- D01479
- PubChem Compound
- 108013
- ChemSpider
- 18567122
- ChEBI
- 31198
- ChEMBL
- CHEMBL1514634
- Predicted Properties
Property Value Source Water Solubility 0.0185 mg/mL ALOGPS logP 3.72 ALOGPS logP 2.65 Chemaxon logS -4.3 ALOGPS pKa (Strongest Acidic) 15.26 Chemaxon pKa (Strongest Basic) 9.01 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 58.28 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 81.94 m3·mol-1 Chemaxon Polarizability 32.8 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon