Disopyramide phosphateProduct ingredient for Disopyramide
- Name
- Disopyramide phosphate
- Drug Entry
- Disopyramide
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
- Accession Number
- DBSALT000899
- Structure
- Synonyms
- Not Available
- UNII
- N6BOM1935W
- CAS Number
- 22059-60-5
- Weight
- Average: 437.477
Monoisotopic: 437.20795814 - Chemical Formula
- C21H32N3O5P
- InChI Key
- CGDDQFMPGMYYQP-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)
- IUPAC Name
- 4-[bis(propan-2-yl)amino]-2-phenyl-2-(pyridin-2-yl)butanamide; phosphoric acid
- SMILES
- OP(O)(O)=O.CC(C)N(CCC(C(N)=O)(C1=CC=CC=C1)C1=CC=CC=N1)C(C)C
- External Links
- KEGG Compound
- C07740
- PubChem Compound
- 30928
- ChemSpider
- 28696
- ChEBI
- 4658
- ChEMBL
- CHEMBL1201020
- Wikipedia
- Disopyramide
- Predicted Properties
Property Value Source Water Solubility 0.0493 mg/mL ALOGPS logP 3.21 ALOGPS logP 3.47 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 16.19 Chemaxon pKa (Strongest Basic) 10.42 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 59.22 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 102.3 m3·mol-1 Chemaxon Polarizability 38.93 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon