Ondansetron hydrochlorideProduct ingredient for Ondansetron

Name
Ondansetron hydrochloride
Drug Entry
Ondansetron

A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a long history of use and efficacy. Commonly formulated as oral tablets, orally disintegrating tablets (ODT), and injections, and available as generic products as well, ondansetron continues to see contemporary innovations in its formulation and use, including the development of orally soluble films that are both discreet in administration and less of a burden in comparison to having patients attempt to swallow pills during emesis.7

The FDA withdrew its approval for the use of all intravenous drug products containing more than 16 mg of ondansetron hydrochloride in a single dose, due to a high risk of QT prolongation.8,9

Accession Number
DBSALT000921
Structure
Synonyms
Ondansetron HCl / Ondansetron hydrochloride anhydrous
UNII
2999F27MAD
CAS Number
99614-01-4
Weight
Average: 329.83
Monoisotopic: 329.12949
Chemical Formula
C18H20ClN3O
InChI Key
MKBLHFILKIKSQM-UHFFFAOYSA-N
InChI
InChI=1S/C18H19N3O.ClH/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2;/h3-6,9-10,13H,7-8,11H2,1-2H3;1H
IUPAC Name
9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one hydrochloride
SMILES
Cl.CN1C2=C(C3=CC=CC=C13)C(=O)C(CN1C=CN=C1C)CC2
ChemSpider
61903
ChEMBL
CHEMBL1201111
Wikipedia
Ondansetron
Predicted Properties
PropertyValueSource
Water Solubility0.248 mg/mLALOGPS
logP2.56ALOGPS
logP2.35Chemaxon
logS-3.1ALOGPS
pKa (Strongest Acidic)15.39Chemaxon
pKa (Strongest Basic)7.34Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area39.82 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity86.78 m3·mol-1Chemaxon
Polarizability33.16 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon