Epinastine hydrochlorideProduct ingredient for Epinastine
- Name
- Epinastine hydrochloride
- Drug Entry
- Epinastine
Epinastine is used for the prevention of itching associated with allergic conjunctivitis. It has a multi-action effect that inhibits the allergic response in 3 ways: 1. stabilizes mast cells by preventing mast cell degranulation to control the allergic response, 2. prevents histamine binding to both the H1- and H2-receptors to stop itching and provide lasting protection, and 3. prevents the release of proinflammatory chemical mediators from the blood vessel to halt progression of the allergic response.
- Accession Number
- DBSALT000961
- Structure
Structure for Epinastine hydrochloride (DBSALT000961)
- Synonyms
- Epinastine HCl
- UNII
- GFM415S5XL
- CAS Number
- 108929-04-0
- Weight
- Average: 285.78
Monoisotopic: 285.1032752 - Chemical Formula
- C16H16ClN3
- InChI Key
- VKXSGUIOOQPGAF-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H15N3.ClH/c17-16-18-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)19(15)16;/h1-8,15H,9-10H2,(H2,17,18);1H
- IUPAC Name
- 2,4-diazatetracyclo[12.4.0.0²,⁶.0⁷,¹²]octadeca-1(18),7,9,11,14,16-hexaen-3-imine hydrochloride
- SMILES
- Cl.N=C1NCC2N1C1=CC=CC=C1CC1=CC=CC=C21
- External Links
- ChemSpider
- 138449
- ChEBI
- 51037
- ChEMBL
- CHEMBL1200491
- Wikipedia
- Epinastine
- Predicted Properties
Property Value Source Water Solubility 0.201 mg/mL ALOGPS logP 2.34 ALOGPS logP 3.13 Chemaxon logS -3.1 ALOGPS pKa (Strongest Basic) 9.31 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 39.12 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 87.19 m3·mol-1 Chemaxon Polarizability 27.56 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon