Mephentermine sulfateProduct ingredient for Mephentermine

Name
Mephentermine sulfate
Drug Entry
Mephentermine

A sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1248)

Accession Number
DBSALT001074
Structure
Synonyms
Not Available
UNII
580655Z8RR
CAS Number
1212-72-2
Weight
Average: 424.6
Monoisotopic: 424.239578821
Chemical Formula
C22H36N2O4S
InChI Key
DNKCFBJMFIUNRS-UHFFFAOYSA-N
InChI
InChI=1S/2C11H17N.H2O4S/c2*1-11(2,12-3)9-10-7-5-4-6-8-10;1-5(2,3)4/h2*4-8,12H,9H2,1-3H3;(H2,1,2,3,4)
IUPAC Name
bis(methyl(2-methyl-1-phenylpropan-2-yl)amine); sulfuric acid
SMILES
OS(O)(=O)=O.CNC(C)(C)CC1=CC=CC=C1.CNC(C)(C)CC1=CC=CC=C1
ChemSpider
64680
ChEBI
6756
ChEMBL
CHEMBL3184799
Wikipedia
Mephentermine
Predicted Properties
PropertyValueSource
Water Solubility0.457 mg/mLALOGPS
logP2.54ALOGPS
logP2.52ChemAxon
logS-2.6ALOGPS
pKa (Strongest Basic)10.3ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area12.03 Å2ChemAxon
Rotatable Bond Count6ChemAxon
Refractivity53.12 m3·mol-1ChemAxon
Polarizability19.74 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon