Danaparoid sodiumProduct ingredient for Danaparoid

Name
Danaparoid sodium
Drug Entry
Danaparoid

Danaparoid is a low-molecular-weight heparinoid with an average molecular weight of 5500 Daltons consisting of a mixture of glycosaminoglycans 2. The active constituents are heparan, dermatan and Chondroitin sulfate 5, and they are isolated from the porcine intestinal mucosa Label. Danaparoid possesses a potent antithrombic activity that works by inhibiting activated factor X (Factor Xa) and activated factor II (Factor IIa). It is chemically distinct from heparin by containing different protein binding properties, thus has lower cross-reactivity in heparin-intolerant patients. Danaproid is used in the treatment of heparin-induced thrombocytopenia (HIT) as an off-label indication and prevention of post-operative deep venous thrombosis (DVT). While it was initially approved by the FDA as Orgaran™, danaparoid was withdrawn by Organon International on August 14, 2002, due to a shortage in drug substance by the manufacturer. The use of Orgaran™ was discontinued in the United States however it is available in several other countries including European countries and Japan. Danaparoid sodium is the common salt form in therapeutic preparations and is typically administered subcutaneously.

Accession Number
DBSALT001136
Synonyms
Sodium danaparoid
External IDs
ORG 10172 / ORG-10172
UNII
5004UU3156
CAS Number
Not Available
Wikipedia
Danaparoid