Nylidrin hydrochlorideProduct ingredient for Nylidrin
- Name
- Nylidrin hydrochloride
- Drug Entry
- Nylidrin
Nylidrin, also known as buphenine belongs to the category of drugs called vasodilators, which relax blood vessels and increase blood flow. Nylidrin is a peripheral vasodilator. Some studies show the evidence of improving cognitive impairment in selected individuals, such as geriatric patients with mild to moderate symptoms of cognitive, emotional and physical impairment 4.
Nylidrin is utilized to treat several disorders that may benefit from increased blood flow (for example, certain mental disorders, blood vessel disease due to diabetes, frostbite, night leg cramps, and certain types of ulcers). This medication works by dilating (widening) blood vessels to help increase blood flow (improving circulation) throughout the body, including the extremities and central nervous system. This effect may help to improve memory/judgment, improve walking ability, and support the healing of frostbite/ulcers 6.
FDA has considered nylidrin as "lacking substantial evidence of effectiveness" in cerebral ischemia, cerebral arteriosclerosis, and other cerebral circulatory insufficiencies. Therefore, the FDA has withdrawn nylidrin from the U.S. market 9.
- Accession Number
- DBSALT001140
- Structure
Structure for Nylidrin hydrochloride (DBSALT001140)
- Synonyms
- Nylidrin HCl
- UNII
- EC69E3PW7E
- CAS Number
- 849-55-8
- Weight
- Average: 335.87
Monoisotopic: 335.1652068 - Chemical Formula
- C19H26ClNO2
- InChI Key
- CLJHABUMMDMAFA-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H25NO2.ClH/c1-14(8-9-16-6-4-3-5-7-16)20-15(2)19(22)17-10-12-18(21)13-11-17;/h3-7,10-15,19-22H,8-9H2,1-2H3;1H
- IUPAC Name
- 4-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]propyl}phenol hydrochloride
- SMILES
- Cl.CC(CCC1=CC=CC=C1)NC(C)C(O)C1=CC=C(O)C=C1
- External Links
- KEGG Drug
- D01543
- ChemSpider
- 12755
- ChEBI
- 31925
- ChEMBL
- CHEMBL1204337
- Predicted Properties
Property Value Source Water Solubility 0.0204 mg/mL ALOGPS logP 2.73 ALOGPS logP 3.05 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 9.25 Chemaxon pKa (Strongest Basic) 10.11 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 52.49 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 90.06 m3·mol-1 Chemaxon Polarizability 34.52 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon