Primaquine phosphateProduct ingredient for Primaquine
- Name
- Primaquine phosphate
- Drug Entry
- Primaquine
An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
- Accession Number
- DBSALT001188
- Structure
Structure for Primaquine phosphate (DBSALT001188)
- Synonyms
- Not Available
- UNII
- H0982HF78B
- CAS Number
- 63-45-6
- Weight
- Average: 455.341
Monoisotopic: 455.122253457 - Chemical Formula
- C15H27N3O9P2
- InChI Key
- GJOHLWZHWQUKAU-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H21N3O.2H3O4P/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14;2*1-5(2,3)4/h4,6,8-11,18H,3,5,7,16H2,1-2H3;2*(H3,1,2,3,4)
- IUPAC Name
- N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine; bis(phosphoric acid)
- SMILES
- OP(O)(O)=O.OP(O)(O)=O.COC1=CC(NC(C)CCCN)=C2N=CC=CC2=C1
- External Links
- ChemSpider
- 5905
- ChEMBL
- CHEMBL43128
- Wikipedia
- Primaquine
- Predicted Properties
Property Value Source Water Solubility 0.0564 mg/mL ALOGPS logP 2.76 ALOGPS logP 1.64 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 17.11 Chemaxon pKa (Strongest Basic) 10.2 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 60.17 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 78.51 m3·mol-1 Chemaxon Polarizability 29.92 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon