Primaquine is an antimalarial indicated to prevent relapse of vivax malaria. An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide.
- Mechanism
- Curator reviewed
Primaquine's mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may bind to and alter the properties of protozoal DNA.
- Primary indication
- For the treatment of malaria.Curator reviewed · 4 structured indications
- Formula / weight
- C15H21N3O · 259.3467 g/mol (avg)
- First approval
- Canada, 2006 · United States, 2011
- Also known as
- Primachin · Primaquin
- Code names
- SN-13272 · WR-2975
Resolves to
INDBQLZJXZLFIT-UHFFFAOYSA-NSMILESCOC1=CC(NC(C)CCCN)=C2N=CC=CC2=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Primaquine, and which of those have an active Phase 3 trial?
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