Molindone hydrochlorideProduct ingredient for Molindone
- Name
- Molindone hydrochloride
- Drug Entry
- Molindone
An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)
- Accession Number
- DBSALT001243
- Structure
- Synonyms
- Molindone HCl
- UNII
- 1DWS68PNE6
- CAS Number
- 15622-65-8
- Weight
- Average: 312.84
Monoisotopic: 312.1604558 - Chemical Formula
- C16H25ClN2O2
- InChI Key
- GQWNECFJGBQMBO-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H
- IUPAC Name
- 3-ethyl-2-methyl-5-[(morpholin-4-yl)methyl]-4,5,6,7-tetrahydro-1H-indol-4-one hydrochloride
- SMILES
- Cl.CCC1=C(C)NC2=C1C(=O)C(CN1CCOCC1)CC2
- External Links
- ChemSpider
- 25517
- ChEBI
- 6966
- ChEMBL
- CHEMBL1200419
- Wikipedia
- Molindone
- Predicted Properties
Property Value Source Water Solubility 0.474 mg/mL ALOGPS logP 2.09 ALOGPS logP 2.04 Chemaxon logS -2.8 ALOGPS pKa (Strongest Acidic) 15.34 Chemaxon pKa (Strongest Basic) 6.65 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 45.33 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 81.06 m3·mol-1 Chemaxon Polarizability 32 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon