Molindone is an antipsychotic used to treat schizophrenia. An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder.
- Mechanism
- Curator reviewed
The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying (antagonizing) dopamine (D2) receptor sites in the reticular limbic systems in the brain, thus decreasing dopamine activity. Decreased dopamine activity results in decreased physiological effects normally induced by excessive dopamine stimulation, such as those typically seen in manifestations of psychotic disorders.
- Primary indication
- Molindone is used for the management of the manifestations of psychotic disorders.Curator reviewed · 1 structured indication
- Formula / weight
- C16H24N2O2 · 276.374 g/mol (avg)
- First approval
- United States, 1974
- Also known as
- (+/-)-molindone
- Code names
- SPN-810
Resolves to
KLPWJLBORRMFGK-UHFFFAOYSA-NSMILESCCC1=C(C)NC2=C1C(=O)C(CN1CCOCC1)CC2What you can answer from here — as of September 23, 2026
Which drugs share a target with Molindone, and which of those have an active Phase 3 trial?
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