Cariprazine hydrochlorideProduct ingredient for Cariprazine
- Name
- Cariprazine hydrochloride
- Drug Entry
- Cariprazine
Cariprazine is an atypical antipsychotic agent and a piperazine derivative that was first developed in Hungary.6 It works as a partial agonist at central dopamine D2, dopamine D3, and serotonin 5-HT1A receptors and as an antagonist at serotonin 5-HT2A receptors.9 Cariprazine has been investigated in a variety of psychiatric disorders, including schizophrenia, bipolar disorders, and major depressive disorder. Cariprazine gained its first global approval in the US in September 2015 2 and was later approved by Health Canada in April 2022.10 It is currently used to treat schizophrenia, and manic or mixed episodes and depressive episodes associated with bipolar I disorder.9
- Accession Number
- DBSALT001260
- Structure
Structure for Cariprazine hydrochloride (DBSALT001260)
- Synonyms
- Cariprazine HCl
- UNII
- KQD7C255YG
- CAS Number
- 1083076-69-0
- Weight
- Average: 463.87
Monoisotopic: 462.1719948 - Chemical Formula
- C21H33Cl3N4O
- InChI Key
- GPPJWWMREQHLQT-BHQIMSFRSA-N
- InChI
- InChI=1S/C21H32Cl2N4O.ClH/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23;/h3-5,16-17H,6-15H2,1-2H3,(H,24,28);1H/t16-,17-;
- IUPAC Name
- 3,3-dimethyl-1-[(1r,4r)-4-{2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl}cyclohexyl]urea hydrochloride
- SMILES
- Cl.CN(C)C(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)C2=C(Cl)C(Cl)=CC=C2)CC1
- External Links
- ChemSpider
- 28504138
- ChEBI
- 90932
- ChEMBL
- CHEMBL2024517
- Wikipedia
- Cariprazine
- Predicted Properties
Property Value Source Water Solubility 0.0279 mg/mL ALOGPS logP 4.56 ALOGPS logP 4.06 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 15.68 Chemaxon pKa (Strongest Basic) 7.91 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 38.82 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 117.81 m3·mol-1 Chemaxon Polarizability 48.36 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon