Trientine hydrochlorideProduct ingredient for Triethylenetetramine

Name
Trientine hydrochloride
Drug Entry
Triethylenetetramine

Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, spermidine and spermine. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925.4 Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease,5 TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and tolerant to penicillamine.8

TETA has been investigated in clinical trials for the treatment of heart failure in patients with diabetes.2,3,4,5,6

Accession Number
DBSALT001269
Structure
Synonyms
Trientine dihydrochloride / Trientine HCl / Trientine hydrochloride / Triethylene tetramine dihydrochloride / Triethylenetetramine dihydrochloride
External IDs
MK 0681 / MK-0681
UNII
HC3NX54582
CAS Number
38260-01-4
Weight
Average: 219.15
Monoisotopic: 218.1065021
Chemical Formula
C6H20Cl2N4
InChI Key
WYHIICXRPHEJKI-UHFFFAOYSA-N
InChI
InChI=1S/C6H18N4.2ClH/c7-1-3-9-5-6-10-4-2-8;;/h9-10H,1-8H2;2*1H
IUPAC Name
(2-aminoethyl)({2-[(2-aminoethyl)amino]ethyl})amine dihydrochloride
SMILES
Cl.Cl.NCCNCCNCCN
KEGG Drug
D00736
ChemSpider
64521
ChEBI
9706
ChEMBL
CHEMBL3989777
Wikipedia
Triethylenetetramine
Predicted Properties
PropertyValueSource
logP-2.2Chemaxon
pKa (Strongest Basic)9.77Chemaxon
Physiological Charge2Chemaxon
Hydrogen Acceptor Count4Chemaxon
Hydrogen Donor Count4Chemaxon
Polar Surface Area76.1 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity43.32 m3·mol-1Chemaxon
Polarizability18.04 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon