Trientine hydrochlorideProduct ingredient for Triethylenetetramine
- Name
- Trientine hydrochloride
- Drug Entry
- Triethylenetetramine
Triethylenetatramine (TETA), also known as trientine, is a potent and selective copper (II)-selective chelator. It is a structural analog of linear polyamine compounds, spermidine and spermine. TETA was first developed in Germany in 1861 and its chelating properties were first recognized in 1925.4 Initially approved by the FDA in 1985 as a second-line treatment for Wilson's disease,5 TETA is currently indicated to treat adults with stable Wilson’s disease who are de-coppered and tolerant to penicillamine.8
TETA has been investigated in clinical trials for the treatment of heart failure in patients with diabetes.2,3,4,5,6
- Accession Number
- DBSALT001269
- Structure
Structure for Trientine hydrochloride (DBSALT001269)
- Synonyms
- Trientine dihydrochloride / Trientine HCl / Trientine hydrochloride / Triethylene tetramine dihydrochloride / Triethylenetetramine dihydrochloride
- External IDs
- MK 0681 / MK-0681