Spermidine

DB03566InvestigationalSmall molecule

Spermidine is a polyamine formed from putrescine. It is found in almost all tissues in association with nucleic acids. It is found as a cation at all pH values, and... It is found as a cation at all pH values, and is thought to help stabilize some membranes and nucleic acid structures.

Chemical structure of Spermidine
Mechanism
Curator reviewed
Formula / weight
C7H19N3 · 145.2459 g/mol (avg)
Also known as
Spermidin

Resolves to

Compound
UNIIU87FK77H25CAS124-20-9ChEMBLCHEMBL19612ChEBI16610PubChem1102KEGGC00315
Clinical / RWD
RxNorm1483262
Structure
InChIKeyATHGHQPFGPMSJY-UHFFFAOYSA-NSMILESNCCCCNCCCN
Targets
Q16881TXNRD1P08588ADRB1P07550ADRB2P23181aacC1P0AFK9potD
Transporters
Q9H015SLC22A4O15245SLC22A1

What you can answer from here — as of September 23, 2026

5Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
2TransportersSubstrate / inhibitor direction, not just membership
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64Drug interactionsStructured to mechanism, not free text
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4Clinical trialsPhase, status and sponsor resolved per trial
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11+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Spermidine, and which of those have an active Phase 3 trial?

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