Mersalyl sodiumProduct ingredient for Mersalyl
- Name
- Mersalyl sodium
- Drug Entry
- Mersalyl
Mersalyl is the sodium salt form of mersalyl acid, a mercurial diuretic. It is an outdated drug, and its approval has been discontinued by the FDA. Mersalyl acid is currently replaced by less toxic non-mercury containing diuretics 4,6. The sodium salt of a mercury-containing derivative of salicylamide, was formerly used (often in combination with theophylline) to treat edema, due to its powerful diuretic properties 6. Interestingly, it has been found to have antiviral properties in mice 13.
- Accession Number
- DBSALT001336
- Structure
Structure for Mersalyl sodium (DBSALT001336)
- Synonyms
- Mercuramide / Mersalyl / Mersalyl sodium component of mersalyl-theophylline / Mersalyl-theophylline component mersalyl sodium
- UNII
- 5X1IO031V8
- CAS Number
- 492-18-2
- Weight
- Average: 505.85
Monoisotopic: 507.058175 - Chemical Formula
- C13H16HgNNaO6
- InChI Key
- WWKZBHGJCDECFG-UHFFFAOYSA-L
- InChI
- InChI=1S/C13H16NO5.Hg.Na.H2O/c1-9(18-2)7-14-13(17)10-5-3-4-6-11(10)19-8-12(15)16;;;/h3-6,9H,1,7-8H2,2H3,(H,14,17)(H,15,16);;;1H2/q;2*+1;/p-2
- IUPAC Name
- sodium (3-{[2-(carboxylatomethoxy)phenyl]formamido}-2-methoxypropyl)mercurylium hydroxide
- SMILES
- [OH-].[Na+].[H]N(CC(C[Hg+])OC)C(=O)C1=CC=CC=C1OCC([O-])=O
- External Links
- Predicted Properties
Property Value Source Water Solubility 3.94 mg/mL ALOGPS logP 1.06 ALOGPS logP 0.2 Chemaxon logS -2.1 ALOGPS pKa (Strongest Acidic) 3.24 Chemaxon pKa (Strongest Basic) -1.3 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 87.69 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 77.92 m3·mol-1 Chemaxon Polarizability 28.47 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon