Amphetamine aspartateProduct ingredient for Amphetamine

Name
Amphetamine aspartate
Drug Entry
Amphetamine

Amphetamine, a compound discovered over 100 years ago, is one of the more restricted controlled drugs. It was previously used for a large variety of conditions and this changed until this point where its use is highly restricted. Amphetamine, with the chemical formula alpha-methylphenethylamine, was discovered in 1910 and first synthesized by 1927. After being proven to reduce drug-induced anesthesia and produce arousal and insomnia, amphetamine racemic mix was registered by Smith, Kline and French in 1935. Amphetamine structure presents one chiral center and it exists in the form of dextro- and levo-isomers.1 The first product of Smith, Kline and French was approved by the FDA on 1976.12

During World War II, amphetamine was used to promote wakefulness in the soldiers. This use derived into a large overproduction of amphetamine and all the surplus after the war finalized ended up in the black market, producing the initiation of the illicit abuse.1

Accession Number
DBSALT001345
Structure
Synonyms
Amfetamine aspartate
UNII
H527KAP6L5
CAS Number
25333-81-7
Weight
Average: 403.523
Monoisotopic: 403.247106555
Chemical Formula
C22H33N3O4
InChI Key
OJNSNSZTGUACNI-VAGRMJETSA-N
InChI
InChI=1S/2C9H13N.C4H7NO4/c2*1-8(10)7-9-5-3-2-4-6-9;5-2(4(8)9)1-3(6)7/h2*2-6,8H,7,10H2,1H3;2H,1,5H2,(H,6,7)(H,8,9)/t;;2-/m..0/s1
IUPAC Name
(2S)-2-aminobutanedioic acid; bis(1-phenylpropan-2-amine)
SMILES
N[C@@H](CC(O)=O)C(O)=O.CC(N)CC1=CC=CC=C1.CC(N)CC1=CC=CC=C1
ChemSpider
7977072
Wikipedia
Amphetamine
Predicted Properties
PropertyValueSource
Water Solubility1.74 mg/mLALOGPS
logP1.85ALOGPS
logP1.8Chemaxon
logS-1.9ALOGPS
pKa (Strongest Basic)10.01Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count1Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area26.02 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity43.71 m3·mol-1Chemaxon
Polarizability16.18 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon