Pramoxine hydrochlorideProduct ingredient for Pramocaine

Name
Pramoxine hydrochloride
Drug Entry
Pramocaine

Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders. Pramocaine is available by itself and in combination with other medications in various topical preparations. It works by preventing ionic fluctuations needed for neuron membrane depolarization and action potential propagation.

Accession Number
DBSALT001353
Structure
Thumb
Synonyms
Pramoxine HCl
UNII
88AYB867L5
CAS Number
637-58-1
Weight
Average: 329.87
Monoisotopic: 329.1757715
Chemical Formula
C17H28ClNO3
InChI Key
SYCBXBCPLUFJID-UHFFFAOYSA-N
InChI
InChI=1S/C17H27NO3.ClH/c1-2-3-12-20-16-5-7-17(8-6-16)21-13-4-9-18-10-14-19-15-11-18;/h5-8H,2-4,9-15H2,1H3;1H
IUPAC Name
4-[3-(4-butoxyphenoxy)propyl]morpholine hydrochloride
SMILES
Cl.CCCCOC1=CC=C(OCCCN2CCOCC2)C=C1
ChemSpider
66586
ChEBI
8358
ChEMBL
CHEMBL1201171
Wikipedia
Pramocaine
Predicted Properties
PropertyValueSource
Water Solubility0.221 mg/mLALOGPS
logP3.03ALOGPS
logP2.84ChemAxon
logS-3.1ALOGPS
pKa (Strongest Basic)7.06ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area30.93 Å2ChemAxon
Rotatable Bond Count9ChemAxon
Refractivity84.82 m3·mol-1ChemAxon
Polarizability35.25 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon