Pramocaine is a local anesthetic and antipruritic agent found in various topical preparations. It is used for many dermatological and anorectal/anogenital conditions including minor cuts/burns, insect bites, hives/rashes due to poison ivy exposure, hemorrhoids and other anorectal/anogenital disorders.
- Mechanism
- Curator reviewed
Pramocaine reversibly binds and inhibits voltage gated sodium channels on neurons decreasing sodium permeability into the cell. This stabilizes the membrane and prevents ionic fluctuations needed for depolarization stopping any action potential propagation.
- Primary indication
- It is indicated for temporary relief of pain and pruritus from minor lip and skin irritations as well as for temporary relief from pain, burning, itching and discomfort associated with hemorrhoids and other anorectal/anogenital disorders.Curator reviewed · 4 structured indications
- Formula / weight
- C17H27NO3 · 293.407 g/mol (avg)
- First approval
- Canada, 1999 · United States, 1977
- Also known as
- Pramoxine
- Brand names
Resolves to
DQKXQSGTHWVTAD-UHFFFAOYSA-NSMILESCCCCOC1=CC=C(OCCCN2CCOCC2)C=C1What you can answer from here — as of September 12, 2026
Which other approved drugs treat the same conditions as Pramocaine, and which companies have late-stage candidates in those indications?
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