Cefpodoxime proxetilProduct ingredient for Cefpodoxime
- Name
- Cefpodoxime proxetil
- Drug Entry
- Cefpodoxime
Cefpodoxime is an oral third generation cephalosporin antibiotic with effectiveness against most Gram positive and Gram negative bacteria. Commonly used to treat acute otitis media, pharyngitis, and sinusitis, cefpodoxime proxetil is a prodrug which is absorbed and de-esterified by the intestinal mucosa to Cefpodoxime.
- Accession Number
- DBSALT001354
- Structure
Structure for Cefpodoxime proxetil (DBSALT001354)
- Synonyms
- Not Available
- UNII
- 2TB00A1Z7N
- CAS Number
- 87239-81-4
- Weight
- Average: 557.59
Monoisotopic: 557.125019817 - Chemical Formula
- C21H27N5O9S2
- InChI Key
- LTINZAODLRIQIX-FBXRGJNPSA-N
- InChI
- InChI=1S/C21H27N5O9S2/c1-9(2)33-21(30)35-10(3)34-19(29)15-11(6-31-4)7-36-18-14(17(28)26(15)18)24-16(27)13(25-32-5)12-8-37-20(22)23-12/h8-10,14,18H,6-7H2,1-5H3,(H2,22,23)(H,24,27)/b25-13-/t10?,14-,18-/m1/s1
- IUPAC Name
- (2Z)-2-(2-imino-2,3-dihydro-1,3-thiazol-4-yl)-2-(methoxyimino)-N-[(6R,7R)-3-(methoxymethyl)-8-oxo-2-[(1-{[(propan-2-yloxy)carbonyl]oxy}ethoxy)carbonyl]-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl]ethanimidic acid
- SMILES
- [H]C(C)(OC(=O)OC(C)C)OC(=O)C1=C(COC)CS[C@@]2([H])N1C(=O)[C@@]2([H])N=C(O)C(=N/OC)\C1=CSC(=N)N1
- External Links
- KEGG Compound
- C08115
- ChemSpider
- 5014485
- BindingDB
- 50248233
- ChEBI
- 3505
- ChEMBL
- CHEMBL1201016
- Wikipedia
- Cefpodoxime
- Predicted Properties
Property Value Source Water Solubility 0.103 mg/mL ALOGPS logP 1.7 ALOGPS logP 2.17 Chemaxon logS -3.7 ALOGPS pKa (Strongest Acidic) 3.73 Chemaxon pKa (Strongest Basic) 0.72 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 11 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 181.43 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 144.67 m3·mol-1 Chemaxon Polarizability 55.21 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon