Levocetirizine dihydrochlorideProduct ingredient for Levocetirizine
- Name
- Levocetirizine dihydrochloride
- Drug Entry
- Levocetirizine
Levocetirizine is a selective histamine H1 antagonist used to treat a variety of allergic symptoms.2,3,4 It is the R enantiomer of cetirizine.4 Levocetirizine has greater affinity for the histamine H1 receptor than cetirizine.4
Levocetirizine was granted FDA approval in 1995.4
- Accession Number
- DBSALT001370
- Structure
- Synonyms
- Levocetirizine diHCl
- UNII
- SOD6A38AGA
- CAS Number
- 130018-87-0
- Weight
- Average: 461.81
Monoisotopic: 460.1087258 - Chemical Formula
- C21H27Cl3N2O3
- InChI Key
- PGLIUCLTXOYQMV-GHVWMZMZSA-N
- InChI
- InChI=1S/C21H25ClN2O3.2ClH/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26;;/h1-9,21H,10-16H2,(H,25,26);2*1H/t21-;;/m1../s1
- IUPAC Name
- 2-(2-{4-[(R)-(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid dihydrochloride
- SMILES
- Cl.Cl.OC(=O)COCCN1CCN(CC1)[C@H](C1=CC=CC=C1)C1=CC=C(Cl)C=C1
- External Links
- ChemSpider
- 8131587
- ChEMBL
- CHEMBL1201190
- Wikipedia
- Levocetirizine
- Predicted Properties
Property Value Source Water Solubility 0.0658 mg/mL ALOGPS logP 2.98 ALOGPS logP 0.87 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 3.59 Chemaxon pKa (Strongest Basic) 7.42 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 53.01 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 106.87 m3·mol-1 Chemaxon Polarizability 41.92 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon