Levocetirizine is an H1-receptor antagonist used to treat symptoms associated with chronic allergic rhinitis and uncomplicated cases of chronic idiopathic urticaria. It is the R enantiomer of cetirizine.
- Mechanism
- Curator reviewed · 2 references
Levocetirizine selectively inhibits histamine H1 receptors. This action prevents histamine from activating this receptor and causing effects like smooth muscle contraction, increased permeability of vascular endothelium, histidine uptake in basophils, stimulation of cough receptors, and stimulation of flare responses in the nervous system.
- Primary indication
- Levocetirizine is indicated to treat symptoms of perennial allergic rhinitis and uncomplicated skin manifestations of chronic idiopathic urticaria.Curator reviewed · 7 structured indications
- Formula / weight
- C21H25ClN2O3 · 388.89 g/mol (avg)
- First approval
- United States, 2007
- Brand names
Resolves to
ZKLPARSLTMPFCP-OAQYLSRUSA-NSMILESOC(=O)COCCN1CCN(CC1)[C@H](C1=CC=CC=C1)C1=CC=C(Cl)C=C1What you can answer from here — as of September 23, 2026
Which drugs share a target with Levocetirizine, and which of those have an active Phase 3 trial?
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