Spirapril hydrochlorideProduct ingredient for Spirapril
- Name
- Spirapril hydrochloride
- Drug Entry
- Spirapril
Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration. ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure.
- Accession Number
- DBSALT001443
- Structure
- Synonyms
- Spirapril HCl
- UNII
- OCC25LM897
- CAS Number
- 94841-17-5
- Weight
- Average: 503.07
Monoisotopic: 502.1362922 - Chemical Formula
- C22H31ClN2O5S2
- InChI Key
- CLDOLNORSLLQDI-OOAIBONUSA-N
- InChI
- InChI=1S/C22H30N2O5S2.ClH/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27;/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27);1H/t15-,17-,18-;/m0./s1
- IUPAC Name
- (8S)-7-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid hydrochloride
- SMILES
- Cl.[H][C@@](C)(N[C@@]([H])(CCC1=CC=CC=C1)C(=O)OCC)C(=O)N1CC2(C[C@@]1([H])C(O)=O)SCCS2
- External Links
- ChemSpider
- 5254098
- ChEMBL
- CHEMBL1200831
- Wikipedia
- Spirapril
- Predicted Properties
Property Value Source Water Solubility 0.0293 mg/mL ALOGPS logP 1.79 ALOGPS logP 1.6 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 3.62 Chemaxon pKa (Strongest Basic) 5.2 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 95.94 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 121.94 m3·mol-1 Chemaxon Polarizability 49.19 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon