Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration. ACE inhibitors are used primarily in treatment of hypertension and...
- Mechanism
- Curator reviewed
Spiraprilat, the active metabolite of spirapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Spiraprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.
- Primary indication
- Spirapril is an ACE inhibitor class drug used to treat hypertension.Curator reviewed
- Formula / weight
- C22H30N2O5S2 · 466.614 g/mol (avg)
- Code names
- Sch 33844
Resolves to
HRWCVUIFMSZDJS-SZMVWBNQSA-NSMILESCCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2(C[C@H]1C(O)=O)SCCS2What you can answer from here — as of September 23, 2026
Which drugs share a target with Spirapril, and which of those have an active Phase 3 trial?
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