Flumethasone acetateProduct ingredient for Flumethasone
- Name
- Flumethasone acetate
- Drug Entry
- Flumethasone
Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a privalate salt, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.
- Accession Number
- DBSALT001651
- Structure
- Synonyms
- Flumethasone 21-acetate
- UNII
- HB84ATQ00X
- CAS Number
- 2823-42-9
- Weight
- Average: 452.495
Monoisotopic: 452.201045012 - Chemical Formula
- C24H30F2O6
- InChI Key
- ISSQQUKLQJHHOR-OSNGSNEUSA-N
- InChI
- InChI=1S/C24H30F2O6/c1-12-7-15-16-9-18(25)17-8-14(28)5-6-21(17,3)23(16,26)19(29)10-22(15,4)24(12,31)20(30)11-32-13(2)27/h5-6,8,12,15-16,18-19,29,31H,7,9-11H2,1-4H3/t12-,15+,16+,18+,19+,21+,22+,23+,24+/m1/s1
- IUPAC Name
- 2-[(1R,2R,3aS,3bS,5S,9aS,9bR,10S,11aS)-5,9b-difluoro-1,10-dihydroxy-2,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethyl acetate
- SMILES
- [H][C@@]12C[C@@H](C)[C@](O)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
- External Links
- ChemSpider
- 9330306
- ZINC
- ZINC000038309959
- Predicted Properties
Property Value Source Water Solubility 0.0301 mg/mL ALOGPS logP 2.41 ALOGPS logP 1.78 Chemaxon logS -4.2 ALOGPS pKa (Strongest Acidic) 12.44 Chemaxon pKa (Strongest Basic) -3.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 100.9 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 111.47 m3·mol-1 Chemaxon Polarizability 45.02 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon