Flumethasone is a corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions. Flumethasone is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties.
- Mechanism
- Curator reviewed
Flumethasone is a glucocorticoid receptor agonist. This complex binds to the nucleus causing a variety of genetic activation and repressions. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding. Flumethasone binds to plasma transcortin, and it becomes active when it is not bound to transcortin.
- Primary indication
- For the treatment of contact dermatitis, atopic dermatitis, exczema, psoriasis, diaper rash and other skin conditionsCurator reviewed · 20 structured indications
- Formula / weight
- C22H28F2O5 · 410.458 g/mol (avg)
- First approval
- Canada, 1997
- Also known as
- Flumetasone
- Code names
- NSC-54702 · RS 2177 · U-10,974
- Brand names
Resolves to
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Which drugs share a target with Flumethasone, and which of those have an active Phase 3 trial?
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