Sodium iodide I-123Product ingredient for Iodide I-123
- Name
- Sodium iodide I-123
- Drug Entry
- Iodide I-123
Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123.
Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4). Radioactive I-123 in particular is effective for this use as its half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a reduced radiation burden as compared to I-131.
- Accession Number
- DBSALT002459
- Structure
Structure for Sodium iodide I-123 (DBSALT002459)
- Synonyms
- Sodio ioduro (123I) / Sodium iodide (123 I) / Sodium iodide (123I) / Sodium iodide I 123 / Sodium iodide, I-123 / Sodium iodide,I-123
- UNII
- 29UKX3A616
- CAS Number
- 41927-88-2
- Weight
- Average: 145.8954
Monoisotopic: 145.89536722 - Chemical Formula
- INa
- InChI Key
- FVAUCKIRQBBSSJ-VVUPZWBASA-M
- InChI
- InChI=1S/HI.Na/h1H;/q;+1/p-1/i1-4;
- IUPAC Name
- sodium (123I)iodide
- SMILES
- [Na+].[123I-]
- External Links
- ChemSpider
- 9172363
- ChEMBL
- CHEMBL1201083
- Predicted Properties
Property Value Source logP 1.02 Chemaxon pKa (Strongest Acidic) -9 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 0 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 0 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 13.95 m3·mol-1 Chemaxon Polarizability 5.07 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon