Sodium thiosulfateProduct ingredient for Thiosulfuric acid
- Name
- Sodium thiosulfate
- Drug Entry
- Thiosulfuric acid
Thiosulfuric acid is available in its salt forms sodium thiosulfate and sodium thiosulfate pentahydrate. Sodium thiosulfate is part of the World Health Organization’s list of essential medicines, and it has a variety of industrial uses, including food preservative, water de-chlorinator and paper pulp bleaching agent.1 Sodium thiosulfate is rapidly degraded in the stomach; therefore, it is normally administered through other routes, such as intravenous or topical.1 Sodium thiosulfate is approved for the treatment of acute cyanide poisoning5,6,2 and it is frequently used in conjunction with sodium nitrite (a salt form of nitrous acid). Sodium thiosulfate is also used to reduce the risk of ototoxicity associated with cisplatin.7 When administered 6 hours after cisplatin chemotherapy, Sodium thiosulfate leads to a lower incidence of cisplatin-induced hearing loss among children without affecting its effectiveness.3,4
- Accession Number
- DBSALT002504
- Structure
Structure for Sodium thiosulfate (DBSALT002504)
- Synonyms
- Sodium thiosulfate anhydrous
- UNII
- L0IYT1O31N
- CAS Number
- 7772-98-7
- Weight
- Average: 158.108
Monoisotopic: 157.908424596 - Chemical Formula
- Na2O3S2
- InChI Key
- AKHNMLFCWUSKQB-UHFFFAOYSA-L
- InChI
- InChI=1S/2Na.H2O3S2/c;;1-5(2,3)4/h;;(H2,1,2,3,4)/q2*+1;/p-2
- IUPAC Name
- disodium 1-oxo-1lambda6-disulfene-1,1-bis(olate)
- SMILES
- [Na+].[Na+].[O-]S([O-])(=O)=S
- External Links
- ChemSpider
- 22885
- ChEBI
- 132112
- ChEMBL
- CHEMBL3753202
- Wikipedia
- Sodium_thiosulfate
- Predicted Properties
Property Value Source logP 0.048 Chemaxon pKa (Strongest Acidic) 2.7 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 63.19 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 19.52 m3·mol-1 Chemaxon Polarizability 7.76 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon