Oglufanide disodiumProduct ingredient for Oglufanide
- Name
- Oglufanide disodium
- Drug Entry
- Oglufanide
Oglufanide is a synthetic dipeptide immunomodulator in development for the treatment of chronic hepatitis C viral infection. Oglufanide was originally developed to treat severe infectious disease in Russia (where it is a registered pharmaceutical), and was extensively studied in cancer clinical trials in the United States before being acquired by Implicit Bioscience in 2005. Oglufanide works as a regulator of the body's immune response, is being given by intranasal administration to patients with chronic hepatitis C viral infection.
- Accession Number
- DBSALT002546
- Structure
Structure for Oglufanide disodium (DBSALT002546)
- Synonyms
- Glufanide disodium
- External IDs
- IM-862 / IM862
- UNII
- Q60AU1LLNU
- CAS Number
- 237068-57-4
- Weight
- Average: 377.308
Monoisotopic: 377.09635922 - Chemical Formula
- C16H17N3Na2O5
- InChI Key
- GDLPAGOVHZLZEK-JBUFHSOLSA-L
- InChI
- InChI=1S/C16H19N3O5.2Na/c17-11(5-6-14(20)21)15(22)19-13(16(23)24)7-9-8-18-12-4-2-1-3-10(9)12;;/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24);;/q;2*+1/p-2/t11-,13-;;/m0../s1
- IUPAC Name
- disodium (4S)-4-amino-4-{[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]carbamoyl}butanoate
- SMILES
- [Na+].[Na+].N[C@@H](CCC([O-])=O)C(=O)N[C@@H](CC1=CNC2=CC=CC=C12)C([O-])=O
- External Links
- ChemSpider
- 139673
- ChEMBL
- CHEMBL2107123
- Predicted Properties
Property Value Source Water Solubility 1.97 mg/mL ALOGPS logP 1.04 ALOGPS logP -2.2 Chemaxon logS -2.3 ALOGPS pKa (Strongest Acidic) 3.44 Chemaxon pKa (Strongest Basic) 8.45 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 151.17 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 105.96 m3·mol-1 Chemaxon Polarizability 32.74 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon