Naphazoline nitrateProduct ingredient for Naphazoline

Show full entry for Naphazoline
Name
Naphazoline nitrate
Drug Entry
Naphazoline

Naphazoline is a rapid acting imidazoline sympathomimetic vasoconstrictor of ocular or nasal artierioles6,7. It acts to decrease congestion and is found in many over the counter (OTC) eye drops and nasal preparations6,7.

Naphazoline was first developed in 1942 as a nasal formulation for congestion4.

See full entry for Naphazoline
Accession Number
DBSALT002621
Structure
Similar Structures
Synonyms
Not Available
UNII
SC99GR1T5S
CAS Number
5144-52-5
Weight
Average: 273.292
Monoisotopic: 273.111341355
Chemical Formula
C14H15N3O3
InChI Key
ZAHXYMFVNNUHCP-UHFFFAOYSA-N
InChI
InChI=1S/C14H14N2.HNO3/c1-2-7-13-11(4-1)5-3-6-12(13)10-14-15-8-9-16-14;2-1(3)4/h1-7H,8-10H2,(H,15,16);(H,2,3,4)
IUPAC Name
2-[(naphthalen-1-yl)methyl]-4,5-dihydro-1H-imidazole; nitric acid
SMILES
O[N+]([O-])=O.C(C1=NCCN1)C1=CC=CC2=C1C=CC=C2
KEGG Drug
D01021
ChemSpider
74303
ChEBI
7471
Predicted Properties
PropertyValueSource
Water Solubility0.0381 mg/mLALOGPS
logP3.44ALOGPS
logP2.19Chemaxon
logS-3.7ALOGPS
pKa (Strongest Basic)10.19Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area24.39 Å2Chemaxon
Rotatable Bond Count2Chemaxon
Refractivity65.52 m3·mol-1Chemaxon
Polarizability23.77 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon