Pirlindole lactateProduct ingredient for Pirlindole
- Name
- Pirlindole lactate
- Drug Entry
- Pirlindole
This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA drug). It was developed and is currently used as an antidepressant in Russia. Its chemical structure is similar to metralindole, and it also shares pharmacological properties with this drug.
Pirlindole is a selective, reversible inhibitor of monoamine oxidase (MAO) subtype A (MAO-A) that is approved in several European and non-European countries for the treatment of major depression. The antidepressant efficacy and safety of pirlindole have been demonstrated in numerous studies and, supported by many years of clinical experience in the treatment of depression. Pirlindole's efficacy and safety have also been shown in the treatment of fibromyalgia.
- Accession Number
- DBSALT002871
- Structure
Structure for Pirlindole lactate (DBSALT002871)
- Synonyms
- Not Available
- UNII
- PRE19MC9Y9
- CAS Number
- 292039-20-4
- Weight
- Average: 316.401
Monoisotopic: 316.178692641 - Chemical Formula
- C18H24N2O3
- InChI Key
- PXRNCRKTECAYRB-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H18N2.C3H6O3/c1-10-5-6-14-12(9-10)11-3-2-4-13-15(11)17(14)8-7-16-13;1-2(4)3(5)6/h5-6,9,13,16H,2-4,7-8H2,1H3;2,4H,1H3,(H,5,6)
- IUPAC Name
- 12-methyl-1,4-diazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-9(16),10,12,14-tetraene; 2-hydroxypropanoic acid
- SMILES
- CC(O)C(O)=O.CC1=CC=C2N3CCNC4CCCC(=C34)C2=C1
- External Links
- ChemSpider
- 23868179
- Predicted Properties
Property Value Source Water Solubility 0.107 mg/mL ALOGPS logP 2.1 ALOGPS logP 3.1 Chemaxon logS -3.3 ALOGPS pKa (Strongest Basic) 8.7 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 16.96 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 70.42 m3·mol-1 Chemaxon Polarizability 27.27 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon