Pirlindole

DB09244ExperimentalSmall molecule

This drug is classified as a reversible inhibitor of monoamine oxidase A enzyme (also known as a RIMA drug). It was developed and is currently used as an antidepressant in... Its chemical structure is similar to metralindole, and it also shares pharmacological properties with this drug.

Mechanism: This drug is a selective and reversible inhibitor of monoamine oxidase A (also known as MAO-A). Its main mechanism of action is selective and reversible inhibition of monoamine oxidase A. Its secondary mechanism of action is the inhibition effect of noradrenaline and 5-hydroxytryptamine reuptake.
Curator reviewed · 1 reference
Primary indication: For the treatment of major depression.Curator reviewed
Formula / weight: C₁₅H₁₈N₂ · 226.323 g/mol (avg)

Resolves to

Compound

UNIIV39YPH45FZCAS60762-57-4ChEMBLCHEMBL32350ChEBI91755PubChem68802KEGGD08392

Structure

InChIKeyIWVRVEIKCBFZNF-UHFFFAOYSA-NSMILESCC1=CC=C2N3CCNC4CCCC(=C34)C2=C1

Targets

P21397MAOAP08908HTR1AP08913ADRA2A

What you can answer from here — as of August 30, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action

Listed above

1,743Drug interactionsStructured to mechanism, not free text

11+ReferencesStructured and connected to the statements they support

Which drugs share a target with Pirlindole, and which of those have an active Phase 3 trial?

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