Methotrimeprazine hydrochlorideProduct ingredient for Methotrimeprazine

Name
Methotrimeprazine hydrochloride
Drug Entry
Methotrimeprazine

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

Accession Number
DBSALT002963
Structure
Thumb
Synonyms
Levomepromazine HCl / Levomepromazine hydrochloride / Levomepromazinium chloride / Methoxy-3 (dimethylamino-3 methyl-2 propyl)-10 phenothiazine hydrochloride
UNII
42BB1Y2586
CAS Number
1236-99-3
Weight
Average: 364.93
Monoisotopic: 364.1376123
Chemical Formula
C19H25ClN2OS
InChI Key
ODLGFPIWRAEFAN-PFEQFJNWSA-N
InChI
InChI=1S/C19H24N2OS.ClH/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21;/h5-11,14H,12-13H2,1-4H3;1H/t14-;/m1./s1
IUPAC Name
[(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine hydrochloride
SMILES
Cl.COC1=CC2=C(SC3=C(C=CC=C3)N2C[C@H](C)CN(C)C)C=C1
ChemSpider
10128525
ChEBI
31773
ChEMBL
CHEMBL2104973
Predicted Properties
PropertyValueSource
Water Solubility0.00525 mg/mLALOGPS
logP4.84ALOGPS
logP4.25ChemAxon
logS-4.8ALOGPS
pKa (Strongest Basic)9.42ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area15.71 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity99.83 m3·mol-1ChemAxon
Polarizability36.77 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon