Methotrimeprazine maleateProduct ingredient for Methotrimeprazine

Name
Methotrimeprazine maleate
Drug Entry
Methotrimeprazine

A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)

Accession Number
DBSALT002992
Structure
Synonyms
Levomepromazine maleate / Methotrimeprazine maleate
UNII
5KN5Y9V01K
CAS Number
7104-38-3
Weight
Average: 444.55
Monoisotopic: 444.171893184
Chemical Formula
C23H28N2O5S
InChI Key
IFLZPECPTYCEBR-VIEYUMQNSA-N
InChI
InChI=1S/C19H24N2OS.C4H4O4/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21;5-3(6)1-2-4(7)8/h5-11,14H,12-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-;/m1./s1
IUPAC Name
(2Z)-but-2-enedioic acid; [(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine
SMILES
OC(=O)\C=C/C(O)=O.COC1=CC2=C(SC3=C(C=CC=C3)N2C[C@H](C)CN(C)C)C=C1
ChemSpider
4445627
ChEMBL
CHEMBL1725730
Predicted Properties
PropertyValueSource
Water Solubility0.00525 mg/mLALOGPS
logP4.84ALOGPS
logP4.25Chemaxon
logS-4.8ALOGPS
pKa (Strongest Basic)9.42Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area15.71 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity99.83 m3·mol-1Chemaxon
Polarizability37.13 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon