Methotrimeprazine maleateProduct ingredient for Methotrimeprazine
- Name
- Methotrimeprazine maleate
- Drug Entry
- Methotrimeprazine
A phenothiazine with pharmacological activity similar to that of both chlorpromazine and promethazine. It has the histamine-antagonist properties of the antihistamines together with central nervous system effects resembling those of chlorpromazine. (From Martindale, The Extra Pharmacopoeia, 30th ed, p604)
- Accession Number
- DBSALT002992
- Structure
- Synonyms
- Levomepromazine maleate / Methotrimeprazine maleate
- UNII
- 5KN5Y9V01K
- CAS Number
- 7104-38-3
- Weight
- Average: 444.55
Monoisotopic: 444.171893184 - Chemical Formula
- C23H28N2O5S
- InChI Key
- IFLZPECPTYCEBR-VIEYUMQNSA-N
- InChI
- InChI=1S/C19H24N2OS.C4H4O4/c1-14(12-20(2)3)13-21-16-7-5-6-8-18(16)23-19-10-9-15(22-4)11-17(19)21;5-3(6)1-2-4(7)8/h5-11,14H,12-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-;/m1./s1
- IUPAC Name
- (2Z)-but-2-enedioic acid; [(2R)-3-(2-methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]dimethylamine
- SMILES
- OC(=O)\C=C/C(O)=O.COC1=CC2=C(SC3=C(C=CC=C3)N2C[C@H](C)CN(C)C)C=C1
- External Links
- ChemSpider
- 4445627
- ChEMBL
- CHEMBL1725730
- Predicted Properties
Property Value Source Water Solubility 0.00525 mg/mL ALOGPS logP 4.84 ALOGPS logP 4.25 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 9.42 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 15.71 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 99.83 m3·mol-1 Chemaxon Polarizability 37.13 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon