Levosalbutamol sulfateProduct ingredient for Levosalbutamol
- Name
- Levosalbutamol sulfate
- Drug Entry
- Levosalbutamol
Levosalbutamol, or levalbuterol, is a short-acting β2 adrenergic receptor agonist used in the treatment of asthma and chronic obstructive pulmonary disease (COPD). Salbutamol has been marketed as a racemic mixture, although beta2-agonist activity resides almost exclusively in the (R)-enantiomer. The enantioselective disposition of salbutamol and the possibility that (S)-salbutamol has adverse effects have led to the development of an enantiomerically pure (R)-salbutamol formulation known as levosalbutamol (levalbuterol).
- Accession Number
- DBSALT002993
- Structure
Structure for Levosalbutamol sulfate (DBSALT002993)
- Synonyms
- Levalbuterol sulfate / Levosalbutamol sulfate
- UNII
- 71TH42O2CQ
- CAS Number
- 148563-16-0
- Weight
- Average: 576.7
Monoisotopic: 576.271666799 - Chemical Formula
- C26H44N2O10S
- InChI Key
- BNPSSFBOAGDEEL-NMFAMCKASA-N
- InChI
- InChI=1S/2C13H21NO3.H2O4S/c2*1-13(2,3)14-7-12(17)9-4-5-11(16)10(6-9)8-15;1-5(2,3)4/h2*4-6,12,14-17H,7-8H2,1-3H3;(H2,1,2,3,4)/t2*12-;/m00./s1
- IUPAC Name
- bis(4-[(1R)-2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl)phenol); sulfuric acid
- SMILES
- OS(O)(=O)=O.CC(C)(C)NC[C@H](O)C1=CC(CO)=C(O)C=C1.CC(C)(C)NC[C@H](O)C1=CC(CO)=C(O)C=C1
- External Links
- ChemSpider
- 9679967
- ChEMBL
- CHEMBL3989589
- Predicted Properties
Property Value Source Water Solubility 2.15 mg/mL ALOGPS logP 0.44 ALOGPS logP 0.34 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 10.12 Chemaxon pKa (Strongest Basic) 9.4 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 72.72 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 67.87 m3·mol-1 Chemaxon Polarizability 26.86 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon