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Lorlatinib
go.drugbank.com/drugs/DB12130ApprovedInvestigationalLorlatinib is a third-generation ALK tyrosine kinase inhibitor (TKI) for patients with ALK-positive metastatic non-small cell lung cancer which was first approved by the US FDA in November of 2018. It was subsequently approved by the EMA...
Categories: P-glycoprotein inducers, Cytochrome P-450 SubstratesBexagliflozin
go.drugbank.com/drugs/DB12236ApprovedInvestigationalBexagliflozin is a highly specific and potent sodium-glucose co-transporter 2 (SGLT2) inhibitor. Similar to other SGLT2 inhibitors, bexagliflozin contains three basic moieties: glucose, two benzene rings and a methylene bridge. SGLT2 is ...
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesBrigatinib
go.drugbank.com/drugs/DB12267ApprovedInvestigationalBrigatinib, originally named AP26113, is a reversible dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). It presents selectivity against the mutant forms of EGFR compared to the wild-type. It ...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersSparsentan
go.drugbank.com/drugs/DB12548ApprovedInvestigationalSparsentan is a dual antagonist of the endothelin type A receptor (ETAR) and the angiotensin II (Ang II) type 1 receptor (AT1R) with a similar affinity for both (9.3 nM for ETAR and 0.8 nM for AT1R). Sparsentan is first in its class and ...
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesMacimorelin
go.drugbank.com/drugs/DB13074ApprovedMacimorelin, a novel and orally active ghrelin mimetic that stimulates GH secretion, is used in the diagnosis of adult GH deficiency (AGHD). More specifically, macimorelin is a peptidomimetic growth hormone secretagogue (GHS) that acts a...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesDiethyl ether
go.drugbank.com/drugs/DB13598InvestigationalCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 InducersCloprednol
go.drugbank.com/drugs/DB13843InvestigationalCloprednol is a synthetic glucocorticoid that has been investigated for use in the treatment of asthma.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersCandesartan
go.drugbank.com/drugs/DB13919InvestigationalCandesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is available as a prodrug in the form of candesartan cilexetil.
Mixtures: CANDESARTAN E IDROCLOROTIAZIDE DOC GENERICI, CANDESARTAN E IDROCLOROTIAZIDE DOC GENERICICategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesBromotheophylline
go.drugbank.com/drugs/DB14018ApprovedBromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the s...
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesHydrocortisone acetate
go.drugbank.com/drugs/DB14539ApprovedInvestigationalVet approvedCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Inducers