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Displaying results 1011 - 1020 of 10000 in total
  1. Drug

    Rivanicline

    go.drugbank.com/drugs/DB05855
    Experimental

    Rivanicline (TC-2403, RJR-2403, (E)-metanicotine) is a partial agonist at neuronal nicotinic acetylcholine receptors, binding primarily to the α4β2 subtype. … It was originally developed as a potential treatment for Alzheimer's disease for its nootropic effects but has also been found to inhibit the production of Interleukin-8.

    Synonyms: (3E)-N-methyl-4-(pyridin-3-yl)but-3-en-1-amine, (E)-N-Methyl-4-(3-pyridinyl)-3-butene-1-amineCategories: Heterocyclic Compounds, 1-Ring
  2. Drug

    Etoposide

    go.drugbank.com/drugs/DB00773
    ApprovedInvestigational

    Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. … A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one, 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)
  3. Drug

    Dazostinag

    go.drugbank.com/drugs/DB18889
    Investigational

    Dazostinag is under investigation in clinical trial NCT04420884 (A Study of Dazostinag as Single Agent and Dazostinag in Combination With Pembrolizumab in Adults With Advanced or Metastatic Solid Tumors

    Synonyms: 7-Deazainosine, [P(R)]-2′-deoxy-2′-fluoro-5′-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(3′→5′)-7-fluoro-, cyclic (2′→5′)-nucleotide
  4. Drug

    Radotermin

    go.drugbank.com/drugs/DB19127
    Investigational

    Radotermin is under investigation in clinical trial NCT01182337 (A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal Rhgdf-5 for the

    Synonyms: Growth differentiation factor 5 (human), homodimer, Recombinant human growth and differentiation factor-5
  5. Drug

    Triciribine phosphate

    go.drugbank.com/drugs/DB14636
    Investigational

    Synonyms: 3-AMINO-1,5-DIHYDRO-5-METHYL-1-.BETA.-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLENE 5'-(DIHYDROGEN PHOSPHATE), Pentaazaacenaphthylene-5' phosphate ester
  6. Drug

    E1v1.11

    go.drugbank.com/drugs/DB18363
    Experimental

    E1v1.11 is an antisense oligonucleotide targeting the _SMN2_ gene which is under investigation for the treatment of spinal muscular atrophy (SMA).[L48196]

    Synonyms: Phosphorodiamidate morpholino oligomer (5'- CTATATATAGTTATTCAACA -3')
  7. Drug

    Pyridoxine phosphate

    go.drugbank.com/drugs/DB02209
    Investigational

    Synonyms: Pyridoxine 5-phosphateCategories: Vitamin B Complex, Heterocyclic Compounds, 1-Ring
  8. Drug

    Zamaporvint

    go.drugbank.com/drugs/DB18765
    Investigational

    Synonyms: 1h-imidazole-1-acetamide, 5-methyl-n-(5-(2-pyrazinyl)-2-pyridinyl)-4-(2-(trifluoromethyl)-4-pyridinyl)-, 5-methyl-n-(5-(2-pyrazinyl)-2-pyridinyl)-4-(2-(trifluoromethyl)-4-pyridinyl)-1h-imidazole-1-acetamide
  9. Drug

    3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol

    go.drugbank.com/drugs/DB06897
    Experimental

    Synonyms: 3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
  10. Drug

    5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine

    go.drugbank.com/drugs/DB07144
    Experimental

    Synonyms: 5-[(3R)-3-(5-methoxy-2',6'-dimethylbiphenyl-3-yl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine