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Spirapril
go.drugbank.com/drugs/DB01348ApprovedInvestigationalACE inhibitors are used primarily in treatment of hypertension and congestive heart failure. … Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Spirapril is converted to the active spiraprilat after administration.
Categories: Agents Acting on the Renin-Angiotensin SystemLutetium Lu 177 dotatate
go.drugbank.com/drugs/DB13985ApprovedInvestigationalIn a clinical trial involving patients with advanced somatostatin receptor-positive GEP-NET, the treatment of Lutetium Lu 177 dotatate in combination with octreotide resulted in longer progression-free … Lutetium Lu 177 dotatate was approved by the FDA as Lutathera in January 2018 for intravenous injection.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Lu-DOTATATE, [177]Lu-DOTA-TATEObinutuzumab
go.drugbank.com/drugs/DB08935ApprovedInvestigational[A274641] As a result, obinutuzumab induces greater antibody-dependent cellular cytotoxicity (ADCC) and a higher degree of direct cell death compared to rituximab. … [L54521] Like other drugs in its class, obinutuzumab targets the CD20 antigen expressed on the surface of pre-B and mature B lymphocytes, mediating B-cell lysis.
Nalmefene
go.drugbank.com/drugs/DB06230ApprovedInvestigationalWithdrawnNalmefene, a 6-methylene analogue of [naltrexone], is an opioid receptor antagonist. … [L40684] It acts as an antagonist at the mu (μ)-opioid and delta (δ)-opioid receptors and a partial agonist at the kappa (κ)-opioid receptor.
Categories: Drugs Used in Alcohol Dependence, Drugs Used in Addictive DisordersVoretigene neparvovec
go.drugbank.com/drugs/DB13932ApprovedInvestigationalVoretigene Neparvovec-rzyl (VN-rzyl) is an adeno-associated virus vector-based gene therapy.[L1094] An adeno-associated virus is a small virus that infects humans and other primates. … [A31477] An advantage of this adeno-associated virus is the high predictability, unlike retrovirus, as they associate with a specific region of the human cellular genome localized in the chromosome 19.
Synonyms: VN-rzylAcarbose
go.drugbank.com/drugs/DB00284ApprovedInvestigationalAcarbose is a complex oligosaccharide that acts as an inhibitor of several enzymes responsible for the breakdown of complex carbohydrates in the intestines. … Acarbose is therefore used in conjunction with diet, exercise, and other pharmacotherapies for the management of blood sugar levels in patients with type 2 diabetes.
Categories: Drugs Used in DiabetesPariglasgene brecaparvovec
go.drugbank.com/drugs/DB16801Approved[L64050,L64051] The approval covers adults and pediatric patients 8 years of age and older and was based on a statistically significant reduction in daily cornstarch intake, a surrogate endpoint, with … Pariglasgene brecaparvovec-opnr is an adeno-associated virus serotype 8 (AAV8)–based gene therapy for glycogen storage disease type Ia (GSDIa), a disorder caused by deficiency of the enzyme glucose-6-phosphatase
Cantharidin
go.drugbank.com/drugs/DB12328ApprovedInvestigationalCantharidin is a naturally occurring odorless, colorless fatty substance of the terpenoid class that is produced as an oral fluid in the alimentary canal of the male blister beetle. … [A32891, A32892] For its natural purpose, the male blister beetle secretes and presents the cantharidin to a female beetle as a copulatory gift during mating.
Categories: Compounds used in a research, industrial, or household settingBronopol
go.drugbank.com/drugs/DB13960ApprovedL4873] and in other products where it may not primarily be used in the role of a non-medicinal preservative antimicrobial [L4874]. … First synthesized in 1897, bronopol was primarily used as a preservative for pharmaceuticals and was registered in the United States in 1984 for use in industrial bactericides, slimicides and preservatives
Categories: Compounds used in a research, industrial, or household settingDeferiprone
go.drugbank.com/drugs/DB08826ApprovedInvestigationalDeferiprone is an oral iron chelator used as a second line agent in thalassemia syndromes when iron overload from blood transfusions occurs. … Thalassemias are a type of hereditary anaemia due a defect in the production of hemoglobin. As a result, erythropoiesis, the production of new red blood cells, is impaired.
Categories: Compounds used in a research, industrial, or household settingProducts: GPO-L-One Tablet 500mg